Comfort Inn & Suites Santee I-95 is offering accommodations in Santee. This 3-star hotel offers a 24-hour front desk and free WiFi. The hotel features family rooms. All guest rooms at the hotel are equipped with a seating area and a TV with satellite channels. The rooms will provide guests with a fridge. A business center and a gym are available at the property as well as free private parking. Charleston International Airport is 55 miles away.